Xilandro; Your preset/mod looks great, the medium-thumbs test from your screens give the perfect illusion of photograph, so don't doubt about it no more because of some internet kids. It's the best I've seen so far.
Actually I've just found out that your the author of R*hancer, which I used at the time of my playtrough month ago with a custom reshade of mine. I'm surprised you didn't update it thought. (But working weather in XML.. I won't complaint anymore with FO4edit, I promise )

The med-thumb test it the step-back equivalent used in painting for computer illustrations. It's just about looking at your picture in a smaller resolution so you have a better vision of the whole picture (contrast, temperature, values, color relationship etc...) without being disturbed by details. It's usually the first seconds that matter the most, before the brain "computing". (I'm sorry I don't know how to translate this in english).
If you got the right feel during that short time, then you are in good way to succeed in your work. If not, then look at the thumb and try to find what's wrong. If your brain compute too much, use the mirror test. Flip the picture horizontally in order to see it with a fresh eye. Again, it's the first seconds that matters, and if there is something wrong you'll see it almost instantly. A too strong color for example, that is breaking the color relationship in some way. Your eye will go straight on it like a magnet.
At least mine usually does, but perhaps is because of my job conditioning.

I'm amazed that the GTA engine has a full 24 hours cycle for color keys. FO4 only have 8, and some transitions between this color keys can be messy sometimes.
Then it's the same trial-error method, and if I knew that I'll mod the game like I do I would have installed it on my ssd...I can't stand the loading screens no more.