I test your file test38
I use wrapper version of 0.193
with [MEMORY]
ExpandSystemMemoryX64=true
ReduceSystemMemoryUsage=false
DisableDriverMemoryManager=true

with [MEMORY]
ExpandSystemMemoryX64=true
ReduceSystemMemoryUsage=True
DisableDriverMemoryManager=true

With ReduceSystemMemoryUsage=True
i loose 10-15 fps
I notice my alt+tab do not the same job now . i loose focus but not returning on desktop and when i refocus tes5 i can directly play the game (before i must clic start and clic the tes5 windows)
now i must clic on apply change in gui when i change a setting in enbserie with alt tab . sorry for my bad english.
also the setting in game britgness dosent work , no effect.
My spec i5 3570k
amd7950 oc
ssd, 8gb ram
1900x1200
no msaa
Edit: ok i m to slow sorry lol