I'm just posting for the possible but unlikely chance that someone else is as dumb as me: If you use Mod Organizer as your mod manager (and you should, as it's much superior to NMM in my opinion and much more user-friendly than Wyre Bash) then you need to remember the fact that your SkyrimPrefs.ini file should be tweaked from within MO. This is because MO keeps a separate set of ini files, outside of the regular ones. So to get your ENBs working as they should, there is no use changing the values in your SkyrimPrefs.ini located in My Documents. Instead, make your changes by clicking the "Edit Ini" button within Mod Organizer.

Have you ever used BOSS?

Don't know about the MO you're talking about, but BOSS + NMM the one...especially once you have lots of mods, and possible conflicts.

?

Yes, I use BOSS. I'm not sure how that relates to this post, but thanks.