So, nothing at all has changed between the last time I was able to play Skyrim to now.
Now, when I attempt to enter a game, (Continue/Load) I CTD. (With both Wrapper and Injector versions)
I have ENB version 0.250 installed and now I've removed any other presets for troubleshooting purposes.

The only files in my \Skyrim directory (enb related) are:
d3d9.dll
enblocal.ini
enbseries.ini
enbhost.exe

I can load a game successfully when I have "Use Effect" unchecked but once I check the box, the game CTD's.

I set it up so that NO effects are enabled once I click "Use Effect" so I can enable them one at a time and see what's causing the issue, but once I do... CTD

Nothing at all has changed. Why would my game suddenly decide it doesn't like ENB? I FINALLY got my CFX working properly and I've been playing Skyrim happily for weeks... now this.

Probably corrupted/invalid shader files or video drivers updated and won't work with these shaders any more. First of all, make backup, remove shader files (and in enbseries folder too) and then install all my official files, if issue will not be fixed, try older versions of the mod.

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i5-4690k, 16Gb RAM, GTX 1060 6Gb, X-Fi Titanium, Win7 x128
I am INFP, not the brutal, godamnit.