On Skyrim Upscaler page autor saing:
DLSS/FSR2/XeSS don't work with ENB, but you can still use DLAA with ENB since there's no upscaling.
A workaround version with ENB compatiblity is in development, and Boris also said he would do compatiblity from his side, when he does this version will be compatible with ENB.
NOTE That they are two different things, ENB got issue with DRS, that's why it doesn't work with this mod, I made a workaround on my own using a completely different method that's hacky but works. When Boris decides to made compatibility for DRS, this mod will just work without needing any change.