I'm trying to play Fallout 4 with ENB mods but there's an overlay that won't go away (even with END or Shift + Enter). Says it's the Photorealistic ENB Series Helper. Linked pic is with camera against a wall so text is clear.

What's happening: https://imgur.com/a/vuC59

How do I get this to go away?

Ask preset maker or read Nexus page where you downloaded that preset.

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i5-4690k, 16Gb RAM, GTX 1060 6Gb, X-Fi Titanium, Win7 x128
I am INFP, not the brutal, godamnit.

It tells you how to remove it right on the preset page not to mention on the screenshot you shared it actually tells you right there on the screen how to close it :p

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Intel Core i9-9900K CPU @ 3.6 GHz // GeForce RTX 2080 Ti VRAM 11GB // Win10 64 and 64GB Ram // Monitor 2560x1440@144